Open your registry and find the key [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer] 

Create a new DWORD value and name it 'RestrictRun' set the value to equal '1' for enabled or '0' for disabled. 

Then define the applications the are allowed to be run at the key [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer\RestrictRun]. 

Creating a new string value for each application, named as consecutive numbers. 

For Example, 

1 Notepad.exe
2 Regedit.exe
3 winword.exe

Reboot the computer for the changes to take effect. 

Key:[HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Explorer]
Value Name: RestrictRun

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